Rapid whole-genome sequencing (WGS) has been used to track the origins of numerous pathogen outbreaks, from food-borne (E. coli) to water-borne (Vibrio cholerae) illnesses. Most recently, WGS applied to the COVID-19 pandemic has illuminated points of viral introduction into populations, and identified the importance and prevalence of community transmission. In collaboration with researchers at WVU’s Health Science Center, we are building out capacity to sequence and analyze SARS-CoV-2 genomes from West Virginia and surrounding communities.